It`s not sweet… it`s not goodbye… it`s just about waiting!

I took a hard choice this week… the choice is a NO CHAT week 12 april – 18 april 2010 with anybody. It`s hard… but it`s not goodbye. It`s hard because of the conection i got with YOU… I need some time to think things over and we see each other and anybody else on next  sunday night after midnight, kinda monday morning. I know YOU`ll be there and I`ll be there too… nobody else maters… Because I`m hopelessly devoted to you… pentru ca TE IUBESC!

7th day: It`s the bitter-sweet Grapefruit!

The grapefruit (Citrus Paradisi), is a subtropical citrus tree known for its bitter fruit, an 18th-century hybrid first bred in Barbados and subsequently recorded in Jamaica. When found in Barbados it was named the „forbidden fruit”; it is also called the „shaddock”, after its creator.

These evergreen trees are usually found at around 5–6 metres (16–20 ft) tall, although they can reach 13–15 metres (43–49 ft). The leaves are dark green, long (up to 150 mm, or 6 inches) and thin. It produces 5 cm (2 in) white four-petaled flowers. The fruit is yellow-orange skinned and largely oblate, and ranges in diameter from 10–15 cm. The flesh is segmented and acidic, varying in color depending on the cultivars, which include white, pink and red pulps of varying sweetness. The 1929 US Ruby Red (of the Redblush variety) has the first grapefruit patent.

The fruit has only become popular from the late 19th century; before that it was only grown as an ornamental plant. The US quickly became a major producer of the fruit, with orchards in Florida, Texas, Arizona, and California. In Spanish, the fruit is known as toronja or pomelo.

Colors and flavors

Grapefruit comes in many varieties, determinable by color, which is caused by the pigmentation of the fruit in respect of both its state of ripeness and genetic bent. The most popular varieties cultivated today are red, white, and pink hues, referring to the internal pulp color of the fruit. The family of flavors range from highly acidic and somewhat bitter to sweet and tart. Grapefruit mercaptan, a sulfur-containing terpene, is one of the substances which has a strong influence on the taste and odor of grapefruit, compared with other citrus fruits.

Drug interactions

Grapefruit can have a number of interactions with drugs, often increasing the effective potency of compounds. In the field of polyphenolic compounds, grapefruit contains the flavanone naringin, alongside the two furanocoumarins bergamottin and dihydroxybergamottin, which inhibit the protein isoform CYP3A4 predominately in the small intestine, but at higher doses, hepatic CYP3A4 inhibition is present as well. It is via inhibition of this enzyme that grapefruit increases the effects of a variety of drugs by increasing their bioavailability. The effect of grapefruit juice with regard to drug absorption was originally discovered in 1989. However, the effect became well-publicized after being responsible for a number of deaths due to overdosing on medication.

Grapefruit juice may be the first documented, but apple and orange juices have been also implicated in interfering with etoposide, a chemotherapy drug, some beta blocker drugs used to treat high blood pressure, and cyclosporine, taken by transplant patients to prevent rejection of their new organs.

Unlike other fruits, grapefruit contains a large amount of naringin, and it can take up to 72 hours before the effects of the naringin on the CYP3A4 enzyme are seen. This is particularly problematic due to the fact that only 4 oz of grapefruit contain enough naringin to inhibit substrates of CYP3A4.

Grapefruit sweets

In Costa Rica, especially in Atenas, grapefruits are often cooked to remove their sourness, rendering them as sweets; they are also stuffed with dulce de leche, resulting in a dessert called toronja rellena (stuffed grapefruit).

Other uses

Grapefruit peel oil is used in aromatherapy and it is historically known for its aroma.

Grapefruit has also been investigated in cancer medicine pharmacodynamics. Its inhibiting effect on the metabolism of some drugs may allow smaller doses to be used, which can help to reduce costs.

Nutritional properties

Grapefruit is an excellent source of many nutrients and phytochemicals that contribute to a healthy diet. Grapefruit is a good source of vitamin C, contains the fiber pectin, and the pink and red hues contain the beneficial antioxidant lycopene. Studies have shown grapefruit helps lowercholesterol,and there is evidence that the seeds have antioxidant properties. Grapefruit forms a core part of the „grapefruit diet”, the theory being that the fruit’s low glycemic index is able to help the body’s metabolismburn fat.

Grapefruit seed extract (GSE) has been claimed to have strong antimicrobialproperties, with proven activity against bacteria and fungi. However, no studies have demonstrated any efficacy by GSE as an antimicrobial for either bacteria or fungi. Additionally, although GSE is promoted as a highly effective plant-based preservative by some natural personal care manufacturers, studies have shown that the apparent antimicrobial activity associated with GSE preparations is merely due to contamination with syntheticpreservatives.

Since grapefruit juice is known to inhibit enzymes necessary for the clearance of some drugs and hormones, some have hypothesized that grapefruit juice may play an indirect role in the development of hormone-dependent cancers. A 2007 study found a correlation between eating a quarter of grapefruit daily and a 30% increase in risk for breast cancer in post-menopausal women. The study points to the inhibition of CYP3A4 enzyme by grapefruit, which metabolizes estrogen. However, a 2008 study has shown that grapefruit consumption does not increase breast cancer risk and found a significant decrease in breast cancer risk with greater intake of grapefruit in women who never used hormone therapy.

Grapefruit contains large quantities of a simple polyamine called spermidine, which may be related to aging. It is known to be necessary for cell growth and maturation, and as cells age their level of spermidine is known to fall. Scientists have shown that feeding spermidine to worms, fruit flies and yeast significantly prolongs their lifespan. In addition, adding spermidine to the diet of mice decreased molecular markers of aging, and when human immune cells were cultured in a medium containing spermidine, they also lived longer.

•Grapefruit Juice. A number of studies have found a risk for stones from drinking grapefruit juice. In one study, just one 8-ounce cup of grapefruit juice per day increased the risk for forming stones by 44%.

Grapefruit, raw, white, all areas Nutritional value per 100 g (3.5 oz) Energy 138 kJ (33 kcal) Carbohydrates 8.41 g Sugars 7.31 g Dietary fiber 1.1 g Fat 0.10 g Protein 0.69 g Water 90.48 g Thiamine (Vit. B1) 0.037 mg (3%) Riboflavin (Vit. B2) 0.020 mg (1%) Niacin (Vit. B3) 0.269 mg (2%) Pantothenic acid (B5) 0.283 mg (6%) Vitamin B6 0.043 mg (3%) Folate (Vit. B9) 10 μg (3%) Vitamin C 33.3 mg (56%) Calcium 12 mg (1%) Iron 0.06 mg (0%) Magnesium 9 mg (2%) Phosphorus 8 mg (1%) Potassium 148 mg (3%) Zinc 0.07 mg (1%) Manganese 0.013 mg Percentages are relative to US recommendations for adults.
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  1. it’s not sweet….it’s too bitter and too painful!!! I hope I can cope with it…it’s gonna be very hard….love u 2

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